ASYMMETRIC-SYNTHESIS OF BOTH ENANTIOMERS OF INO)-1-[3-METHOXY-2-(1-METHYLETHOXY)PHENYL]ETHANOL

Authors
PHILIPPO C FETT E BOVY P BARRAS M ANGEL I GEORGES G OCHSENBEIN P
Citation
C. Philippo et al., ASYMMETRIC-SYNTHESIS OF BOTH ENANTIOMERS OF INO)-1-[3-METHOXY-2-(1-METHYLETHOXY)PHENYL]ETHANOL, European journal of medicinal chemistry, 32(11), 1997, pp. 881-888
Citations number
18
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
32
Issue
11
Year of publication
1997
Pages
881 - 888
Database
ISI
SICI code
0223-5234(1997)32:11<881:AOBEOI>2.0.ZU;2-J
Abstract
Both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1- methylethoxy) phenyl]ethanol were synthetized by a stereoselective route and evaluat ed in vitro for their uroselectivity in Comparison with other alpha-ad renoceptor agonists. The most potent enantiomer was structurally chara cterized by X-ray crystallographic analysis.