SYNTHESIS AND POTENTIAL COANTHRACYCLINIC ACTIVITY OF SUBSTITUTED (5-IMIDAZO[2,1-B]THIAZOLYLMETHYLENE)-2-INDOLINONES

A compound endowed with coanthracyclinic activity should potentiate th e antitumor activity of anthracyclines report the synthesis and config uration of a series of substituted while counteracting their cardiodep ressant effect. We now the (5-imidazo[2,1-b]thiazolylmethylene)-2-indo linones which were tested for both cardiotonic and cytotoxic activity. Several compounds were potent cytotoxic agents and two of them (in pa rticular 5-imidazo[2,1-b]thiazolylmethylene]-2-indolinone), which show ed even cardiotonic activity, are potential coanthracyclinic agents.