Objective: To determine whether inflamed and uninflamed epidermoid cys
ts differ in the number and/or type of bacteria inhabiting them. Desig
n: A controlled study. We obtained aerobic and anaerobic bacterial cul
ture specimens from 25 inflamed and 25 uninflamed epidermoid cysts. Se
tting: A university medical center. Patients: Nonimmunocompromised adu
lts without recent systemic use of antibiotics. Results: The 2 groups
did not differ significantly with respect to number of bacterial isola
tes, ''no growth'' cultures, and aerobic, anaerobic, or potential path
ogens cultured. Conclusions: The microbiological milieu of inflamed ep
idermoid cysts is similar to that of uninflamed cysts. Possible mechan
isms for inflammation are discussed.