SYNTHESIS OF C-14-LABELED FLUVASTATIN (LESCOL(R))

Authors
TANG YS JONES L SUNAY UB
Citation
Ys. Tang et al., SYNTHESIS OF C-14-LABELED FLUVASTATIN (LESCOL(R)), Journal of labelled compounds & radiopharmaceuticals, 41(1), 1998, pp. 1-7
Citations number
15
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
41
Issue
1
Year of publication
1998
Pages
1 - 7
Database
ISI
SICI code
0362-4803(1998)41:1<1:SOCF(>2.0.ZU;2-7
Abstract
l)-1H-indol-2-yl-3-C-14]-3,5-dihydroxy-6-heptenoic acid, sodium salt ( fluvastatin, 4) was prepared from [C-14] bromoacetyl chloride in a six step synthesis with an overall radiochemical yield of 13.2%. This syn thetic route was chosen because it puts the label in the metabolically stable 3-position of the indole ring.