HYDROCORTISONE CYCLODEXTRIN COMPLEX - COMPLEXATION METHODS AND COMPLEX INCORPORATION IN LIPOSOMES/

Hydrocortisone acetate was complexed with gamma-cyclodextrin to form a hydrocortisone/cyclodextrin inclusion complex. Two con?complexation m ethods were applied i.e. the coprecipitation and spray-drying methods. Drug alone, hydrocortisone/cyclodextrin complex I and hydrocortisone/ cyclodextrin complex II were incorporated into liposomes destined for topical application. The highest achieved entrapment of the drug was e qual for liposomes containing hydrocortisone or hydrocortisone/cyclode xtrin complex II. The complexation, method (spray-drying) and liposome preparation method (dilution of proliposome mixture) are simple and e xhibit great potential for industrial production.