RAPID SYNTHESIS OF (+ -AMINO-1-AMINOMETHYL-2-(HYDROXYMETHYL)CYCLOPROPANE AND AMINO-1-AMINOMETHYL-2-(HYDROXYMETHYL)CYCLOPROPANE, PREPARATIONOF THEIR DICHLOROPLATINUM(II) COMPLEXES, AND CRYSTAL-STRUCTURE OF A DERIVATIVE OF THE (+/-)-(E) ISOMER/

Authors
VERGNE F AITKEN DJ CHIARONI A RICHE C HUSSON HP
Citation
F. Vergne et al., RAPID SYNTHESIS OF (+ -AMINO-1-AMINOMETHYL-2-(HYDROXYMETHYL)CYCLOPROPANE AND AMINO-1-AMINOMETHYL-2-(HYDROXYMETHYL)CYCLOPROPANE, PREPARATIONOF THEIR DICHLOROPLATINUM(II) COMPLEXES, AND CRYSTAL-STRUCTURE OF A DERIVATIVE OF THE (+/-)-(E) ISOMER/, Journal of chemical research. Synopses, (4), 1997, pp. 124
Citations number
34
Categorie Soggetti
Chemistry
Journal title
Journal of chemical research. Synopses → ACNP
ISSN journal
03082342
Issue
4
Year of publication
1997
Database
ISI
SICI code
0308-2342(1997):4<124:RSO(->2.0.ZU;2-#
Abstract
An efficient four-step synthesis of racemic Z and E forms of -amino-1- aminomethyl-2-(hydroxymethyl)cyclopropane is described, along with the preparation and cell-growth inhibition evaluation of the correspondin g dichloroplatinum(II) complexes; the crystal structure of the synthet ic intermediate -[(benzyloxycarbonyl)aminomethyl]-1-dibenzylamino- 2-( hydroxymethyl)cyclopropane has been determined.