A 41-KDA ANTIGEN OF THE RODENT FILARIA ACANTHOCHEILONEMA-VITEAE WITH HOMOLOGIES TO TROPOMYOSIN INDUCES HOST-PROTECTIVE IMMUNE-RESPONSES

Authors
HARTMANN S ADAM R MARTI T KIRSTEN C SEIDINGER S LUCIUS R
Citation
S. Hartmann et al., A 41-KDA ANTIGEN OF THE RODENT FILARIA ACANTHOCHEILONEMA-VITEAE WITH HOMOLOGIES TO TROPOMYOSIN INDUCES HOST-PROTECTIVE IMMUNE-RESPONSES, Parasitology research, 83(4), 1997, pp. 390-393
Citations number
18
Categorie Soggetti
Parasitiology
Journal title
Parasitology research → ACNP
ISSN journal
09320113
Volume
83
Issue
4
Year of publication
1997
Pages
390 - 393
Database
ISI
SICI code
0932-0113(1997)83:4<390:A4AOTR>2.0.ZU;2-I
Abstract
A purified 41-kDa protein of the rodent filaria Acanthocheilonema vite ae was shown to protect jirds against a challenge infection. Subcutane ous immunization with the protein reduced the number of adult worms by up to 65% and the number of circulating microfilariae declined by up to 93% in these animals. The protein is located in the muscle tissues of adult worms and was identified as tropomyosin by N-terminal sequenc ing of the purified protein.