STEREOSPECIFIC INTRAMOLECULAR PROTON-TRANSFER IN THE CYCLIZATION OF GERANYLGERANYL DIPHOSPHATE TO (-)-ABIETADIENE CATALYZED BY RECOMBINANT CYCLASE FROM GRAND FIR (ABIES GRANDIS)

Authors
RAVN MM COATES RM JETTER R CROTEAU RB
Citation
Mm. Ravn et al., STEREOSPECIFIC INTRAMOLECULAR PROTON-TRANSFER IN THE CYCLIZATION OF GERANYLGERANYL DIPHOSPHATE TO (-)-ABIETADIENE CATALYZED BY RECOMBINANT CYCLASE FROM GRAND FIR (ABIES GRANDIS), Chemical communications, (1), 1998, pp. 21-22
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
1
Year of publication
1998
Pages
21 - 22
Database
ISI
SICI code
1359-7345(1998):1<21:SIPITC>2.0.ZU;2-B
Abstract
The cyclization-rearrangement of deuterated geranylgeranyl diphosphate (GGPP) and (+)-copalyl diphosphate (CPP) catalyzed by recombinant (-) -abietadiene synthase from grand fir proceeds with intramolecular prot on transfer from C-19 of GGPP, and from the C-17 pro-E position of CPP , to form the C-16 pro-S methyl group of (-)-abietadiene.