EFFICIENT SYNTHESIS OF BETA-AMINO-ACID AND GAMMA-AMINO-ACID DERIVATIVES USING NEW FUNCTIONALIZED ZINC REAGENTS - ENHANCED STABILITY AND REACTIVITY OF BETA-AMIDO ZINC REAGENTS IN DIMETHYLFORMAMIDE

The new zinc reagents 3 and 4 are not sufficiently stable to be prepar ed efficiently in THF, but they can be prepared in DMF under mild and convenient conditions; subsequent palladium-catalysed coupling with ar omatic iodides gives protected beta- and gamma-amino acids 11 and 12 i n generally good yields.