SYNTHESIS OF BETA-AMINO ESTERS USING THE REFORMATSKY REACTION WITH ALPHA-AMINO NITRILES

Authors
DARTIGUELONGUE C PAYAN S DUVAL O GOMES LM WAIGH RD
Citation
C. Dartiguelongue et al., SYNTHESIS OF BETA-AMINO ESTERS USING THE REFORMATSKY REACTION WITH ALPHA-AMINO NITRILES, Bulletin de la Societe chimique de France, 134(8-9), 1997, pp. 769-772
Citations number
13
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
134
Issue
8-9
Year of publication
1997
Pages
769 - 772
Database
ISI
SICI code
0037-8968(1997)134:8-9<769:SOBEUT>2.0.ZU;2-F
Abstract
The chemical behavior of alpha-amino nitriles towards the Reformatsky reagent has been studied. Tinder certain conditions, secondary aliphat ic alpha-amino nitrile derivatives yielded a mixture of four products consisting of a beta-amino ester, a beta-lactam, a bulky tertiary amin e and a cinnamic derivative. In an aliphatic and an alicyclic, fully n itrogen-substituted example, a beta-aminoester is obtained in high yie ld as the sole product.