Malignant pleural effusions are associated with significant morbidity.
Prompt clinical evaluation followed by aggressive treatment often res
ults in successful palliation. This report summarizes the traditional
and experimental approaches used in the management of malignant pleura
l effusion and provides an attempt at analysis of cost comparison and
resource utilization associated with the use of various sclerosing age
nts. The standard sclerotherapy for malignant pleural effusions has ro
utinely been performed as an inpatient procedure using a large-bore ch
est tube for drainage and instillation of a sclerosing agent. Use of a
small-bore catheter for drainage and pleurodesis is associated with r
educed patient discomfort and appears to be feasible and equally effic
acious in the ambulatory setting. Results with the ambulatory procedur
e are preliminary but promising. Future comparisons with the tradition
al approach will allow therapy to be based not only on efficacy, but a
lso on the use and expense of related resources.