HEMODYNAMIC AND ELECTROENCEPHALOGRAPH RESPONSES TO INTUBATION DURING INDUCTION WITH PROPOFOL OR PROPOFOL FENTANYL/

Purpose: To observe the changes in EEG bispectral index (BIS), 95% spe ctral edge frequency (95% SEF) and median frequency (MF) with haemodyn amic changes to intubation during induction with propofol or propofol and 2 mu g . kg(-1) fentanyl iv, Methods: Twenty four ASA I-II patient s were randomized to receive either propofol infusion preceded by norm al saline (group P: n=12) or propofol preceded by 2 mu g . kg(-1) fent anyl (group PF, n=12), Intubation was performed live minutes after mai ntenance of BIS within 45 +/- 5, EEG and haemodynamic variables were r ecorded at before induction, and before and after intubation. Results: Haemodynamic responses to intubation were greater in group P than in group PF (P < 0.05), Postintubation SBP, DBP and HR increased, compare d with preinduction values, more in group P than in group PF; Postintu bation BIS values increased from 45.5 +/- 3.5 and 44.2 +/- 4.1 to 51.1 +/- 4.1 anti 50.9 +/- 5.3 in groups P and PF, respectively, compared with preintubation values, The BIS values were not different between t reatment groups before and after intubation, and 95% SEF and MF values did not increase after intubation, Conclusion: Fentanyl, 2 mu g . kg( -1) iv, blunted the haemodynamic responses to intubation, but failed t o attenuate the arousal of cerebral cortical activity, The different h aemodynamic responses postintubation but similar BIS and 95% SEF chang es in the two groups suggest that BIS or 95% SEF cannot predict the ha emodynamic responses to intubation during anaesthesia induction with p ropofol and fentanyl.