SYNTHESIS OF 1,2-DIHYDROISOQUINOLINES BY THE REACTION OF ISOQUINOLINEWITH ALLYLTRIBUTYLTIN OR SILYL ENOL ETHERS IN THE PRESENCE OF N-ACYLATING AGENTS

Authors
ITOH T MIYAZAKI M NAGATA K HASEGAWA H OHSAWA A NAKAMURA KT
Citation
T. Itoh et al., SYNTHESIS OF 1,2-DIHYDROISOQUINOLINES BY THE REACTION OF ISOQUINOLINEWITH ALLYLTRIBUTYLTIN OR SILYL ENOL ETHERS IN THE PRESENCE OF N-ACYLATING AGENTS, Heterocycles, 47(1), 1998, pp. 125-128
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
47
Issue
1
Year of publication
1998
Pages
125 - 128
Database
ISI
SICI code
0385-5414(1998)47:1<125:SO1BTR>2.0.ZU;2-3
Abstract
Isoquinolines were allowed to react with allyltributyltin or silyl eno l ethers in the presence of N-acylating agents to give 1-substituted 1 ,2-dihydroisoquinolines in good yields. When a chiral acid chloride wa s used for an activator, a high diastereoselectivity was observed for the addition. The configuration of a major isomer was elucidated by an X-Ray crystallographic analysis.