Growing skull fractures are reported in three infants undergoing crani
al vault surgery for craniosynostosis. Although primary dural injury w
as overt in only one patient, an extensive dural defect with spatially
coincident bony absence was identified in all patients at late explor
ation. The coincidence of dural injury, deficient overlying bone, and
a pulsatile growing brain are necessary conditions for the development
of growing skull fractures. With the advent of increasingly radical c
ranial vault procedures during infancy, the potential for this complic
ation to arise may increase. Definitive correction requires autogenous
tissue reconstruction of the dural and bony defect.