MULTICENTER DOUBLE-BLIND-STUDY OF EFFICACY AND SAFETY OF TERBINAFINE 1-PERCENT CREAM COMPARED WITH BIFONAZOLE 1-PERCENT CREAM IN PATIENTS WITH TINEA-PEDIS MOCCASIN TYPE

In a multicentre double-blind randomized parallel-group study, 78 pati ents with mycologically proven moccasin-type tinea pedis were treated with terbinafine 1% cream or bifonazole 1% cream applied once daily fo r 2 weeks. The demographic data of both groups were comparable. Of 40 patients treated with terbinafine, the treatment was effective (i.e. m ycological and clinical improvement) in 82.5% compared with 63.2% of 3 8 patients treated with bifonazole (P=0.05, test of proportion). Both creams were well tolerated. We conclude that topical terbinafine 1% cr eam is superior to bifonazole 1% cream in the treatment of moccasin-ty pe tinea pedis.