VINCRISTINE THERAPY FOR MAST-CELL TUMORS IN DOGS

Twenty-seven dogs with naturally occurring mast cell tumors were treat ed with weekly IV injections of vincristine (0.75 mg/m(2)) for 4 treat ments. Two dogs (7%) had a partial response. Nine dogs (32%) had treat ment stopped prematurely because of toxicity or a perceived deteriorat ion in their quality of life. We conclude that vincristine is ineffect ive as a sole treatment for measurable mast cell tumors in dogs and pr oduces an undesirable number of adverse reactions. Copyright (C) 1997 by the American College of Veterinary Internal Medicine.