Jr. Middleton et al., HEMOLYSIS ASSOCIATED WITH WATER ADMINISTRATION USING A NIPPLE BOTTLE FOR HUMAN INFANTS IN JUVENILE PYGMY GOATS, Journal of veterinary internal medicine, 11(6), 1997, pp. 382-384
A 4-month-old, 6.8-kg, castrated male pygmy goat was examined for recu
rrent episodic fever and red urine of 7 days' duration. A second, 8-mo
nth-old, 7-kg, intact female pygmy goat was presented for similar clin
ical signs. The red discoloration of the urine in each case was determ
ined to be due to hemolysis with subsequent hemoglobinuria. In both ca
ses, hemolysis and hemoglobinuria were closely associated with the goa
ts consuming large volumes of water from a human infant's nipple bottl
e. A diagnosis of water intoxication-induced hemolysis and hemoglobinu
ria was made. Episodes of hemoglobinuria in the first case were consis
tently associated with dilute (specific gravity <1.010) urine. Water i
ntoxication has been associated with bottle-feeding in human infants a
nd is also widely reported in human psychiatric patients. The small er
ythrocytes in goats appear to be the most sensitive of the domestic sp
ecies to hypotonicity-induced hemolysis. Copyright (C) 1997 by the Ame
rican College of Veterinary Internal Medicine.