DOUBLE HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS PERIPHERAL STEM-CELL RESCUE IN RELAPSED WILMS-TUMOR

We performed double high dose chemotherapy (HDCT) and autologous stem cell rescue (ASCR) on an 8-year-old girl after relapse of Wilms' tumor with unfavorable histology. Relapse occurred while the patient was st ill on first-line therapy and showed multiple adverse prognostic featu res, Since depleted hematopoietic reserves restricted further conventi onal therapy, a double HDCT approach was chosen to achieve maximal dos e intensity, Four years after relapse the girl is in second remission and well. Double HDCT with ASCR may represent a feasible approach to r escue extensively pretreated patients with recurrent Wilms' tumor of u nfavorable histology.