DISPOSITION KINETICS OF AMPICILLIN IN BUBALUS-BUBALIS CALVES

The pharmacokinetics of ampicillin after single i/v dose (10 mg/kg bw) was studied in a group of buffalo calves. The plasma drug concentrati on declined from 19.83+/-0.35 mu g/ml to 0.22+/-0.01 up to 12 hr. The mean values of kinetic parameters for t1/2 alpha., vd(area), Cl-B and T/P ratio were 0.24+/-0.02 hr, 2.90+/-0.11 hr, 1.56+/-0.08 L/kg. 6.22/-0.21 ml/kg/min. and 4.87+/-0.27 respectively. The mean values of K-1 2, K-21, K-2 and K-12/K-21 were 1.17+/-0.13 hr(-1).0.47+/-0.02 hr(-1). 1.40+/-0.06 hr(-1) and 2.42+/-0.18 respectively. The per cent protein binding (in vitro) of ampicillin in the plasma of buffalo calves range d from 19.25 to 28.09. Dosage regimen based on the kinetics of drug ha s been suggested for optimal clinical efficacy.