ENANTIOMER SEPARATION OF [60]FULLERENE DERIVATIVES BY MICRO-COLUMN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING -)-2-(2,4,5,7-TETRANITRO-9-FLUORENYLIDENEAMINOOXY) PROPIONIC-ACID AS CHIRAL STATIONARY-PHASE

The enantiomer separation of [60]fullerene derivatives on the chiral s tationary phase (CSP) -)-2-(2,4,5,7-tetranitro-9-fluorenylideneaminoox y) propionic acid (TAPA) was achieved. A [60]fullerene tris-and hexaki s-adduct with achiral addends and an inherent chiral addition pattern were separated on a micro HPLC column containing R-(-)-TAPA bonded to silica gel as CSP. The stationary phase exhibits an intermediate polar ity and separations were performed using the normal and reversed-phase mode. With the hexakis-adduct, near-baseline separation was achieved. The tris-adduct shows a strong interaction with the CSP expressed by a high retention factor but inferior enantiomer separation. (C) 1997 E lsevier Science B.V.