Im. Lazar et al., EVALUATION OF AN ELECTROSPRAY INTERFACE FOR CAPILLARY ELECTROPHORESIS-TIME-OF-FLIGHT MASS-SPECTROMETRY, Journal of chromatography, 791(1-2), 1997, pp. 269-278
The electrospray technique has developed into a widely used ionization
source for interfacing capillary electrophoresis (CE) to mass spectro
metry (MS). However, its implementation is not always straightforward.
A large number of factors have been found to be important contributor
s to the production of a high quality spray, and the efficient transfe
r of analytes from the CE column into the mass spectrometer can become
, in certain cases, troublesome. An electrospray device which can acco
mmodate operation with a liquid sheath, nebulizing gas and make-up gas
, as well as operation without a liquid sheath in the microelectrospra
y mode, was constructed. The electrospray source was evaluated for eff
icient CE separations, which require the best performance. (C) 1997 El
sevier Science B.V.