NEW THERAPIES IN SYSTEMIC IDIOPATHIC FIBR OSIS

Medical treatment of systemic idiopathic fibrosis is first based on st eroid therapy, of which efficacy is well known for nearly 75% of cases of retroperitoneal fibrosis, but less certain for the other localisat ions of the disease. Studies on the immune-pathological mechanism of s ystemic fibrosis have led to immunosuppressive drug use, such as azath ioprin, cyclophosphamide and methotrexate. Tamoxifen has been tried be cause of its efficacy on desmoid turners and seems to be of great inte rest. Attention is focused on fibrosing cervicitis which may also be t reated with immunosuppressive drugs.