DISTAL GANGRENE IN CRYOGLOBULINEMIA ASSOC IATED WITH HEPATITIS-C VIRUS AND ANTICARDIOLIPIN ANTIBODIES

Authors
JACQ F EMMERICH J HERON E LORTHOLARY O BRUNEVAL P FIESSINGER JN
Citation
F. Jacq et al., DISTAL GANGRENE IN CRYOGLOBULINEMIA ASSOC IATED WITH HEPATITIS-C VIRUS AND ANTICARDIOLIPIN ANTIBODIES, La Revue de medecine interne, 18(4), 1997, pp. 324-327
Citations number
17
Categorie Soggetti
Medicine, General & Internal
Journal title
La Revue de medecine interne → ACNP
ISSN journal
02488663
Volume
18
Issue
4
Year of publication
1997
Pages
324 - 327
Database
ISI
SICI code
0248-8663(1997)18:4<324:DGICAI>2.0.ZU;2-B
Abstract
We report the case of a 63-year old women with toe gangrene, periphera l polyneuropathy, polyarthritis, histologically proven necrotizing vas culitis, in association with type III mixed cryoglobulinemia and hepat itis C virus (HCV) infection. Raised anticardiolipin antibodies (aCL) were found, without beta 2-glycoprotein I. HCV infection is associated with mixed cryoglobulinemia which can cause a vasculitis affecting va rious organs. The pathogenesis of production and clinical significance of aCL could be associated in this case with HCV infection.