DURAL SINUS THROMBOSIS ASSOCIATED WITH ACTIVATED PROTEIN-C RESISTANCE- MR-IMAGING FINDINGS AND PROBAND IDENTIFICATION

OBJECTIVE, The purpose of this study was to report the association of dural sinus thrombosis with a hypercoagulable state associated with ac tivated protein C resistance. CONCLUSION. In our small study populatio n, hemorrhagic venous infarction was common (three of four patients) a mong patients with dural sinus thrombosis and activated protein C resi stance. Four of five patients with dural sinus thrombosis had positive tests for activated protein C resistance. This finding, in conjunctio n with data from other studies, suggests that patients with dural sinu s thrombosis may need to be studied for the presence of activated prot ein C resistance. A positive finding for activated protein C resistanc e can be important not only in helping to explain the cause of thrombo sis in affected individuals but also in identifying families at risk f or thrombosis.