Ss. Deshpande et al., CHEMOPREVENTIVE EFFICACY OF CURCUMIN-FREE AQUEOUS TURMERIC EXTRACT IN7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED RAT MAMMARY TUMORIGENESIS, Cancer letters, 123(1), 1998, pp. 35-40
The modulating effects of turmeric (T), ethanolic turmeric extract (ET
E) and curcumin-free aqueous turmeric extract (CFATE) on the initiatio
n or post-initiation phases of DMBA-induced mammary tumorigenesis were
investigated in female Sprague-Dawley rats. Dietary administration of
1% T/0.05% ETE 2 weeks before, on the day of DMBA treatment (day 55)
and 2 weeks after the single dose (15 mg/animal) of DMBA (during the i
nitiation period) resulted in significant suppression of DMBA-induced
mammary tumorigenesis as seen by a reduction in tumor multiplicity, tu
mor burden and tumor incidence. However, simultaneous administration o
f 1% T-derived CFATE as the sole source of drinking water during the i
nitiation phase did not suppress DMBA-induced mammary tumorigenesis. D
ietary administration of 1% T/0.05% ETE or 1% T-derived CFATE as the s
ole source of drinking water starting 48 h after DMBA treatment and co
ntinuing until the end of the experiment (during the post-initiation p
eriod) resulted in significant suppression of DMBA-induced mammary tum
origenesis as seen by reduction in the tumor multiplicity and/or tumor
burden although tumor incidence was unaffected. The present data clea
rly indicate that dietary administration of T/ETE showed strong chemop
reventive activity during initiation as well as postinitiation phases
of DMBA-induced rat mammary tumorigenesis while CFATE was found to be
weakly active only when it was administered during the post-initiation
phase. (C) 1998 Elsevier Science Ireland Ltd.