HELICOBACTER-PYLORI PROMOTES DEVELOPMENT OF PEPSINOGEN-ALTERED PYLORIC GLANDS, A PRENEOPLASTIC LESION OF GLANDULAR STOMACH OF BALB C MICE PRETREATED WITH N-METHYL-N-NITROSOUREA/

H. pylori is thought to be a stomach carcinogen. Since no experimental model has hitherto been established to clarify the relationship betwe en H. pylori and stomach carcinogenesis, the effects of infection with the bacteria on experimental carcinogenesis in the glandular stomach of mice were investigated. BALB/c mice were given salty diet or N-meth yl-N-nitrosourea (MNU) and administered broth culture of H. pylori. Th e incidence of pepsinogen-altered pyloric glands, considered as precan cerous lesions, was increased in the H. pylori inoculated group pre-tr eated with MNU. The findings provide the new experimental model demons trating the relationship between stomach cancer and H. pylori. (C) 199 8 Elsevier Science Ireland Ltd.