A METHOD FOR MEASURING CAPILLARY BLEEDING-TIME IN NON-ANESTHETIZED DOGS - PROLONGATION OF THE BLEEDING-TIME BY ACETYLSALICYLIC-ACID

A reproducible standardized method for measuring capillary bleeding ti me (CBT) in dogs is presented. The skin was punctured at the toe from a forelimb of non-anaesthetized dogs parallel to the edge of the horny skin of the pad. Before the procedure, a cuff of a sphygmometer was p laced above the antibrachium and a hyperaemie agent was applied to the shaved area. The normal CBT in non-anaesthetized dogs was 2.25 +/- 0. 76 min (x +/- SD). After injection of acetylsalicylic acid (ASA) (20 m g/kg body weight), CBT was prolonged up to 25 min. Platelet aggregatio n in response to 10 mu g collagen/ml was decreased in parallel after t reatment with ASA.