K. Amano et al., SUCCESSFUL TREATMENT OF SUPRAVENTRICULAR TACHYCARDIA WITH FLECAINIDE ACETATE - A CASE-REPORT, Fetal diagnosis and therapy, 12(6), 1997, pp. 328-331
Background: Efficacy of flecainide acetate for the treatment of fetal
supraventricular tachycardia with cardiac failure was reported. Case:
For a case in which maternal digoxin therapy failed, flecainide acetat
e (400 mg/day) is used from 27 weeks. Cardioversion with improved card
iac function occurred 6 days after treatment. Fetal serum flecainide a
cetate level was 292 ng/ml which was 64% of the maternal level (453 ng
/ml). No adverse maternal side effects were noted with 11 weeks of the
rapy. A vigorous male baby, weighing 3,610 g, Apgar 8/9, Ua-pH 7.24, w
as born. He is now 1 year of age and in good condition with medication
of 5 mg/kg flecainide acetate. Conclusion: Flecainide acetate seemed
to be safe for bath mother and fetus, and effective for the treatment
of fetal supraventricular tachycardia which is refractory to transplac
ental digoxin therapy.