This review article forecasts developments in nuclear medicine instrum
entation which are on the horizon. Special attention is paid to the ph
ysical properties of detectors and multiple-processor parallel process
ing systems needed for fast and high-quality imaging in emission tomog
raphy. Advances in detector technology will improve imaging resolution
below 5 mm and will increase sensitivity and quantitative accuracy. I
n addition, high count rate list-mode acquisition enables `true' four-
dimensional datasets. A sandwich-like construction of two different cr
ystals allows the simultaneous use of conventional tracers and positro
n tracers (multiple emission tomography, MET). Transmission-based atte
nuation and scatter compensation with fast iterative reconstruction me
thods will further improve image quality. The clinical and scientific
importance of improved images and the limits on advances in instrument
ation are also reviewed.