Radionuclide ventriculography in the best septal view is an establishe
d method to assess both global and regional ventricular function. Addi
tional projections may be used to delineate the wall motion of inferio
r myocardial segments. Radionuclide ventriculography was performed in
65 patients using both a single plane (in the best septal view) and a
biplane technique. The biplane collimator allowed simultaneous assessm
ent in two planes 40 degrees apart, allowing simultaneous visualizatio
n of all four myocardial walls. Seventeen patients with regional wall
motion abnormalities were detected with the single plane best septal v
iew and a further 18 patients with impaired wall motion were identifie
d with the biplane collimator (51% of the abnormal ventricles). The ad
ditional abnormal segments were seen in only the steep lateral project
ion. Left ventricular ejection fraction estimation with the biplane te
chnique remains highly reproducible and correlates well with that deri
ved from the best septal view. Biplane radionuclide ventriculography i
mproves the detection of inferior wall motion abnormalities at no expe
nse of time, and offers the possibility of performing two-view stress
ventriculography with inotropic agents.