A RETROSPECTIVE MOLECULAR ANALYSIS OF GENTAMICIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS STRAINS FROM UK HOSPITALS

Authors
WRIGHT CL BYRNE ME FIRTH N SKURRAY RA
Citation
Cl. Wright et al., A RETROSPECTIVE MOLECULAR ANALYSIS OF GENTAMICIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS STRAINS FROM UK HOSPITALS, Journal of Medical Microbiology, 47(2), 1998, pp. 173-178
Citations number
30
Categorie Soggetti
Microbiology
Journal title
Journal of Medical Microbiology → ACNP
ISSN journal
00222615
Volume
47
Issue
2
Year of publication
1998
Pages
173 - 178
Database
ISI
SICI code
0022-2615(1998)47:2<173:ARMAOG>2.0.ZU;2-B
Abstract
The composite transposon Tn4001, and a related chromosomal Tn4001-like element, encode resistance to the aminoglycosides gentamicin, tobramy cin and kanamycin (GmTmKm(r)) in Australian strains of Staphylococcus aureus. Southern hybridisation analysis of GmTmKm(r) S. aureus strains isolated from various hospitals in the UK between 1975 and 1985 indic ated that they predominantly encoded chromosomal copies of Tn4001 or a Tn4001-like element. However, a strain isolated in 1985 was found to carry Tn4001 on a plasmid related to pSK1, the prototypical multiresis tance plasmid commonly detected in S. aureus strains from Australian h ospitals.