HELICOBACTER-PYLORI, EFFICACY OF THE NEW TRIPLE THERAPY IN 6 AND 12-DAY SCHEDULES

Objective: assessment of four eradicating patterns of 6 and 12 days du ration with new triple therapies adapted to our environment. Patients: after an endoscopic diagnosis of Duodenal or Gastric Ulcer, and the c onfirmation of the presence of Helicobacter pylori using a vapid useas e test in antral biopsies, 274 patients were treated with one of four eradicating therapies, verifying its efficacy with the C-13 urea breat h test, at least one month after the end of the treatment and 10 days after withdrawal of proton pump inhibitors. Results: maximum eradicati ng efficacy was achieved with Omeprazol (20 mg/12 hours), Claritromyci n (500 mg/12 hours) and Amoxycillin (1 g/12 hours), given for 12 days (96.6%), and Omeprazol (20 mg/12 hours), Tinidazol (500 mg/12 hours) a nd Claritromycin (500 mg/12 hours), also given for 12 days (95.2%). Th e same drugs and doses, when given during six days, achieved percentag es of 78.3% and 82.2% respectively. Results with Tinidazol suggest lac k of resistance to this drug in the Community of Madrid.