R. Hussain et al., SIGNIFICANTLY INCREASED IGG2 SUBCLASS ANTIBODY-LEVELS TO BLASTOCYSTIS-HOMINIS IN PATIENTS WITH IRRITABLE-BOWEL-SYNDROME, The American journal of tropical medicine and hygiene, 56(3), 1997, pp. 301-306
Citations number
23
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Blastocystis hominis is a common intestinal parasite of humans in the
tropics whose pathogenic role is in dispute. Its presence has been rep
orted in a variety of intestinal disorders resembling irritable bowel
syndrome (IBS) such as diarrhea, anorexia, and flatulence. We have the
refore investigated a possible link between IBS and blastocystosis by
determining IgG antibody levels to B. hominis in patients with IBS. Le
vels of IgG antibodies were significantly elevated in patients with IB
S compared with asymptomatic controls (P < 0.0001, by Student's t-test
) in both B. hominis stool culture-positive and stool culture-negative
IBS patients. When IgG antibodies were divided into their respective
subclasses, only IgG2 levels were significantly increased in IBS patie
nts compared with asymptomatic controls, indicating that the predomina
nt response in these patients may be directed to carbohydrate antigens
. The diagnostic usefulness of this test in IBS patients remains to be
established because these data are only suggestive of a possible link
between B. hominis and IBS. However, we hope that this antibody test
will help in elucidating the controversy that surrounds the role of B.
hominis as a pathogen at present.