H. Schmidt et al., DETECTION OF NUMERICAL CHROMOSOMAL CHANGES IN 20 MALIGNANT FIBROUS HISTIOCYTOMAS BY FISH, International journal of oncology, 12(2), 1998, pp. 395-402
We investigated 20 malignant fibrous histiocytomas (MFHs) with the hel
p of specific centromeric probes for chromosomes 1, 3, 4, 6, 8, 9, 12,
16, 17 and 18. The results show a broad variation in the number of si
gnals per nucleus. However, tumors can be assigned into four groups: i
) with mostly disomic clones, ii) with a high percentage of polysomic
clones, iii) with a considerable amount of monosomic and nullisomic cl
ones and iv) with a tendency in both directions. A gain of-spots per n
ucleus takes place in 75-100% of the investigated tumors - the highest
incidence occurring with respect to chromosome 3. A loss of spots per
nucleus occurred in 20-60% of the tumors - predominantly with respect
to chromosome 1.