IMMUNOEXPRESSION OF E-CADHERIN AND BETA-CATENIN CORRELATES TO SURVIVAL OF PATIENTS WITH HEPATOCELLULAR CARCINOMAS

Authors
GARCIA S MARTINI F DEMICCO C ANDRAC L HARDWIGSEN J SAPPA P LAVAUT MN LETREUT YP CHARPIN C
Citation
S. Garcia et al., IMMUNOEXPRESSION OF E-CADHERIN AND BETA-CATENIN CORRELATES TO SURVIVAL OF PATIENTS WITH HEPATOCELLULAR CARCINOMAS, International journal of oncology, 12(2), 1998, pp. 443-447
Citations number
26
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
12
Issue
2
Year of publication
1998
Pages
443 - 447
Database
ISI
SICI code
1019-6439(1998)12:2<443:IOEABC>2.0.ZU;2-O
Abstract
Expression of E-cadherin (E-cad) and beta-catenin (beta-cat) was inves tigated immunohistologically in 91 cases of excised hepatocellular car cinomas. Immunodectection was altered in 56% of tumours for E-cad and in 30.8% for beta-cat. Downregulation of E-cad and beta-cat correlated with the size of tumours, and high nuclear grade, but only E-cad alte ration correlated with the mitotic index. Alterations of E-cad and bet a-cat expression correlated with survival. Although E-cad and beta-cat immunodetections were independent prognostic factors, their prognosti c value was lower than that of current clinicopathological parameters.