SULPIRIDE IN PROPHYLACTIC TREATMENT OF MI GRAINE

The aim of the work was investigation of both efficacy of sulpiride, a typical neuroleptic drug with pronounced antidepressive activity, and its influence on central nervous system. The study was performed in th e course of prophylactic treatment of migraine using Contingent Negati ve Variation (CNV) index. It is demonstrated that sulpiride is effecti ve in prophylactic treatment of migraine complicated with psychologic disorders and autonomic dysfunctions. Such effect may be caused by the drug's influence on depression, anxiety, autonomic symptoms, tension- type headaches. This conclusion was confirmed by CNV data, change of w hich after sulpiride administration have indicated normalization of me ntal performance and increase of active adaptive abilities.