COMPATIBILITY OF IBUPROFEN AND ETHENZAMIDE

The compatibility of ibuprofen and various drugs was investigated by t hermal analysis. The results showed a lower melting point with many dr ugs. The compound of ibuprofen and ethenzamide was selected for detail ed compatibility investigation. First, a ratio composition of a eutect ic of ibuprofen and ethenzamide was estimated. A ratio composition of a eutectic of ibuprofen and ethenzamide of weight ratio 3:2 was sugges ted, and its melting point was approximately 56 degrees C. Further, we investigated crystallization by powder x-ray diffraction. The resulti ng powder x-ray diffraction pattern of the compound that was heat trea ted was almost the same as that of the physical mixture, indicating th at the crystallinity of ibuprofen and ethenzamide were not affected tr y the heat treatment. Next, we investigated the chemical stability of ibuprofen, ethenzamide, and a small amount of various excipients in ca psule form, stored under conditions of 65 degrees, 50 degrees, and 40 degrees C. It was established that ibuprofen and ethenzamide are stabl e. However, it was found that there is a remarkable delay of dissoluti on speed under conditions above 50 degrees C.