STABILITY OF CEFAZOLIN IN PLURONIC F-127 GELS

As a part of studies on the possible application of pluronic F-127 gel s for drug delivery systems, an investigation was carried out to chara cterize cefazolin stability in aqueous pluronic F-127 gels. Pseudo-fir st-order rate constants for the cefazolin degradation were obtained fr om different concentrations of pluronic F-127 gels at temperatures of 35 degrees, 45 degrees and 55 degrees C. Rate measurements were also c arried out in the gels composed of different pluronic F-127 concentrat ions (20%, 25%, and 30% w/v).