ENANTIOSELECTIVE SYNTHESIS OF NOVEL ENANTIOPURE PHOSPHINES VIA REACTION OF A TRICARBONYL(ETA(6)-ARENE)CHROMIUM COMPLEX WITH A CHIRAL LITHIUM AMIDE BASE

Authors
ARIFFIN A BLAKE AJ LI WS SIMPKINS NS
Citation
A. Ariffin et al., ENANTIOSELECTIVE SYNTHESIS OF NOVEL ENANTIOPURE PHOSPHINES VIA REACTION OF A TRICARBONYL(ETA(6)-ARENE)CHROMIUM COMPLEX WITH A CHIRAL LITHIUM AMIDE BASE, Synlett, (12), 1997, pp. 1453-1455
Citations number
15
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
12
Year of publication
1997
Pages
1453 - 1455
Database
ISI
SICI code
0936-5214(1997):12<1453:ESONEP>2.0.ZU;2-S
Abstract
A range of novel phosphorus-containing tricarbonyl(eta(6)-arene)chromi um complexes has been synthesised via the enantioselective ortho-metal lation approach using a chiral lithium amide base. Initial asymmetric reaction of a phosphine oxide complex allows the preparation of silyl- or stannyl-substituted products in ca. 73% ee, which then allows the p reparation of other phosphine derivatives in very high ee (>95%) follo wing phosphine reduction and enantiomeric enrichment.