AN EFFICIENT METHOD FOR THE SYNTHESIS OF A NOVEL LEUKOTRIENE B-4 RECEPTOR ANTAGONIST, ONO-4057, VIA MICHAEL REACTION OF DIHYDRORESORCINOL

Authors
KONNO M NAKAE T SAKUYAMA S IMAKI K NAKAI H HAMANAKA N
Citation
M. Konno et al., AN EFFICIENT METHOD FOR THE SYNTHESIS OF A NOVEL LEUKOTRIENE B-4 RECEPTOR ANTAGONIST, ONO-4057, VIA MICHAEL REACTION OF DIHYDRORESORCINOL, Synlett, (12), 1997, pp. 1472-1474
Citations number
5
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
12
Year of publication
1997
Pages
1472 - 1474
Database
ISI
SICI code
0936-5214(1997):12<1472:AEMFTS>2.0.ZU;2-Y
Abstract
A practical method for the synthesis of ONO-4057, a highly potent and orally active leukotriene B-4 (LTB4) receptor antagonist, was develope d. This method includes improved synthesis of a key intermediate, 1,3- dioxo-2-(2-ethoxycarbonylethyl)cyclo (6).