ANTI-DERMAPTOPHYTE ACTIVITY OF PHENOLIC-COMPOUNDS IN MOKUSAKU-EKI

''Mokusaku-eki,'' a kind of pyroligneous acid, is a dark brown color s olution obtained from the charcoal burner of such Quercus spp. woods a s a by-product. This is used as a folk medicine in water eczema. The n -hexane fraction of this solution contained several phenolic compounds such as 4-ethyl-2-methoxyphenol (3) and 2,6-dimethoxyphenol (4), whic h could not be found in the fresh woods. Among these compounds, 3 has the highest anti-dermaptophyte activity against Trichophyton mentagrop hytes at minimum inhibitory concentration (MIG) 150 mu g/ml.