ANTIINFLAMMATORY, ANALGESIC AND ANTI-PYRETIC EFFECTS OF D-2-[4-(3-METHYL-2-THIENYL)PHENYL]PROPIONIC ACID (M-5011), A NEW NONSTEROIDAL ANTIINFLAMMATORY DRUG, IN RATS AND GUINEA-PIGS

Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-met hyl-2-thienyl)phenyl] propionic acid (M-5011), a new non-steroidal ant i-inflammatory drug (NSAID), were compared with those of indomethacin, diclofenac sodium and ketoprofen in rats and guinea pigs. Anti-inflam matory effect of M-5011 on ultraviolet-induced erythema in guinea pigs was 11.7 and 1.8 times more potent than that of indomethacin and keto profen, respectively. Inhibitory effect of M-5011 on carrageenin-induc ed paw edema was 2 and 1.5 times more potent than that of indomethacin and diclofenac sodium, respectively. Analgesic effect of M-5011 on dr y yeast-induced hyperalgesia or adjuvant-induced arthritic pain was eq uipotent to that of indomethacin, diclofenac sodium or ketoprofen. Ant i-pyretic effect of M-5011 on yeast-induced pyrexia in rats was 4.2 an d 4.6 times more potent than that of indomethacin and ketoprofen, resp ectively. Inhibitory effect of M-5011 on prostaglandin E-2 production in the exudate of air-pouch inflammation induced by carrageenin was 1. 75 times more potent than that in the non-inflamed site (stomach). As a result, gastric ulcerogenic activity of M-5011 was half that of indo methacin in rat. These results suggest that M-5011 shows more potent a nti-inflammatory and anti-pyretic effects and equipotent analgesic eff ect with low gastro-ulcerogenic activity compared with classical NSAID s.