STEREOSELECTION AT THE STEADY-STATE BY STEREOCONVERGENT REACTION TOPOGRAPHY

A novel strategy for achieving stereoselection by engineering reaction s to occur through a unique kinetic scheme is introduced. The strategy , named ''complex stereoselection'', effects stereoselection as a resu lt of intermediates at the steady state partitioning successively betw een competing chemical transformations. A mathematical description of the ratio of products produced in the kinetic strategy is derived, and computer simulation of that model demonstrates two principal advantag es of this method: higher selectivity and more efficient conversion of substrates. These computer simulations were subsequently used to dete rmine conditions for maximum stereoselection in these reactions via th e framework of a series of hypothetical scenarios in six different inc arnations of complex stereoselection. The resulting predictions presen t challenges to the field of experimental stereochemistry.