THE AML14 AND AML14.3D10 CELL-LINES - A LONG-OVERDUE MODEL FOR THE STUDY OF EOSINOPHILS AND MORE

Over the past three decades, a number of myeloid cell lines have been established and have proven useful for the study of various aspects of normal and disordered hematopoiesis. However, one myeloid lineage for which a useful cell line model has been sorely lacking is the eosinop hil. We review the characteristics of the recently developed AML14 and AML14.3D10 cell lines and summarize how they hare been used to obtain important new information relevant to eosinophil biology. Observation s regarding the apparent ability of the AML14.3D10 cell line to ''swit ch'' lineages and to produce and use GM-CSF in an autocrine fashion ar e also reviewed.