PATHOLOGY OF DISAPPEARING BONE-DISEASE - A CASE-REPORT WITH IMMUNOHISTOCHEMICAL STUDY

A case of disappearing bone disease of the proximal femur is reported with histopathological and immunohistochemical studies. There was a de nsely packed cellular tissue, positive to endothelial antibodies, in a reas of massive bone destruction, A more differentiated vascular tissu e was present where trabecular cancellous or cortical bone was preserv ed with only, focal zones of accelerated bone remodelling, The self-li mited course correlates well with two phases of evolution of the histo pathological lesions with neoplastic-like proliferation of endothelial cells corresponding to the rapid and massive bone destruction, and a later differentiation of the cells in mature vascular structures, but still with accelerated bone resorption which is partly compensated by appositional activity.