THROMBOSIS IN CONGENITAL DEFICIENCIES OF AT-III, PROTEIN-C OR PROTEIN-S - A STUDY OF 44 CHILDREN

Congenital deficiency in coagulation inhibitors is a cause of heredita ry thrombotic disease. The severity of symptoms is variable and depend s on the type of deficit. In this paper, 44 children suffering from de ep venous thrombosis, with a mean age of 5 years, were studied. A sear ch for Lupus anticoagulant (LA) and coagulation inhibitor deficiency s howed: 3/44 cases (6.8%) had protein S deficiency, 2/44 cases (4.5%) h ad protein C deficiency, 1/44 cases (2.3%) had deficiencies in both pr otein C and S; no cases of AT III deficiency and LA was positive in 2/ 44 cases (4.5%). Only 1 case of APC resistance out of 13 studied was f ound. Four family studies were performed and confirmed the congenital origin of the disorder.