EFFECTS OF PHENCYCLIDINE (PCP) AND (-801 ON SENSORIMOTOR GATING IN CD-1 MICE()MK)

1. Male CD-1 mice were tested for prepulse inhibition (PPI) following admistration of PCP and the PCP site ligand, (+)MK-801, as well as the dopamine (DA) agonist (-)-apomorhine and DA releaser d-amphetamine. S imilar to reports in rats, PCP (0.36 -36.0 mu mol/kg), (+)MK-801 (0.03 -3.0 mu mol/kg), (-)-apomorphine (3.3 and 10.0 mu mol/kg) and d-amphet amine (3.0 and 8.0 mu mol/kg) significantly reduced PPI when administe red to testing. 2. Because PCP also binds to sigma receptors, the auth ors tested the sigma ligand (+)-3-PPP at (118 mu mol/kg) which margina lly increased the PPI. 3. Haloperidol (1.1 mu mol/kg) pretreatment att enuated the reduction in PPI following (-)-apomorphine (10.0 mu mol/kg ), however no effects of haloperidol or clozapine pretreatment on (+)M K-801 disruption of PPI were observed. 4. Because of the pharmacologic al similarities between mouse data and previously published rat data, it is concluded that the mouse is a viable alternative to the rat for testing PPI.