ANTIANGIOGENIC THERAPY AND DERMATOLOGY - A REVIEW

The first decade of angiogenesis research led to the isolation and clo ning of angiogenesis stimulatory molecules. More recent studies have l ed to the isolation and cloning of angiogenesis inhibitors. These mole cules include both peptides and small molecular weight compounds. The mechanisms of action of these compounds are not fully understood, but will likely involve modulation of the phosphoinositol-3-kinase and MAP kinase pathways. These agents have impressive antitumor activity in e xperimental animals, and may prove to be extremely useful for the trea tment of malignant and nonmalignant disorders in patients.