E. Diakomanolis et al., LOCAL VASOCONSTRICTIVE EFFECT OF ORNIPRESSIN (POR8) IN LASER CONIZATION OF THE CERVIX - A RANDOMIZED STUDY, Journal of gynecologic surgery, 13(4), 1997, pp. 187-190
To evaluate the amount of bleeding in patients who underwent laser exc
ision of the transformation zone, the ectocervix was infiltrated with
30 ml of a 1:30 ratio of ornipressin (POR8)-lignocaine 1% solution rat
her than with a 1% 30 mi solution of lignocaine alone. One hundred wom
en undergoing CO2 laser excision of the transformation zone for cervic
al intraepithelial neoplasia (GIN) were randomly allocated to one of t
wo groups (A, POR8-lignocaine group, B, lignocaine group). A standard
protocol that included operative technique, estimation of blood loss,
operative time, pain, and morbidity was used. Statistical analysis was
performed using Student's t-test, chi square, and the Fisher's exact
test. The use of 30 mi of a 1:30 POR8-lignocaine 1% solution resulted
in less intraoperative blood loss (30.25 +/- 3.1 ml vs. 39 +/- 5.2 ml,
p < 0.001). The operative time was 17.5 +/- 1.20 min in group A vs. 2
5.25 +/- 2.5 min in group B. The dimension of the excised specimens we
re similar. No statistical difference was found in the two groups rega
rding the pain experienced. No electrocardiographic anomaly was record
ed. Blood pressure was moderately elevated in the POR8 group (p < 0.3
by Fisher's exact test). Infiltration of the ectocervix with 30 mi of
a 1:30 POR8-lignocaine 1% solution reduced the amount of blood loss du
ring laser excision of the transformation zone.