LOCAL VASOCONSTRICTIVE EFFECT OF ORNIPRESSIN (POR8) IN LASER CONIZATION OF THE CERVIX - A RANDOMIZED STUDY

To evaluate the amount of bleeding in patients who underwent laser exc ision of the transformation zone, the ectocervix was infiltrated with 30 ml of a 1:30 ratio of ornipressin (POR8)-lignocaine 1% solution rat her than with a 1% 30 mi solution of lignocaine alone. One hundred wom en undergoing CO2 laser excision of the transformation zone for cervic al intraepithelial neoplasia (GIN) were randomly allocated to one of t wo groups (A, POR8-lignocaine group, B, lignocaine group). A standard protocol that included operative technique, estimation of blood loss, operative time, pain, and morbidity was used. Statistical analysis was performed using Student's t-test, chi square, and the Fisher's exact test. The use of 30 mi of a 1:30 POR8-lignocaine 1% solution resulted in less intraoperative blood loss (30.25 +/- 3.1 ml vs. 39 +/- 5.2 ml, p < 0.001). The operative time was 17.5 +/- 1.20 min in group A vs. 2 5.25 +/- 2.5 min in group B. The dimension of the excised specimens we re similar. No statistical difference was found in the two groups rega rding the pain experienced. No electrocardiographic anomaly was record ed. Blood pressure was moderately elevated in the POR8 group (p < 0.3 by Fisher's exact test). Infiltration of the ectocervix with 30 mi of a 1:30 POR8-lignocaine 1% solution reduced the amount of blood loss du ring laser excision of the transformation zone.