GRANULOCYTE-COLONY-STIMULATING FACTOR IN NEUTROPENIC PATIENTS WITH INFECTIVE ENDOCARDITIS

A well known complication in the treatment of infectious endocarditis is development of neutropenia caused by treatment with antibiotics in high concentrations over long periods. Neutropenia often necessitates discontinuation of antibiotic treatment. Three patients with infectiou s endocarditis who developed neutropenia are reported. The patients we re treated with granulocyte colony stimulating factor (G-CSF), a haema topoietic growth factor that stimulates neutrophils. G-CSF induced an immediate increase in white blood cell count, primarily neutrophils. G -CSF may be effective in ameliorating neutropenia in patients who rece ive antibiotics for treatment of infectious endocarditis.